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KMID : 0857020040190010226
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Kosin Medical Journal
2004 Volume.19 No. 1 p.226 ~ p.231
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Combination Therapy of Fluoride and Low Dose Estrogen in Postmenopausal Osteopenia
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Kim Ghi-Chan
Jeong Ho-Joong
Shin Jeong-Beom
Chung Suk-Mo
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Abstract
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Background : To investigate the changes of BMD, biochemical bone markers and lipid profiles after combination therapy of Fluoride and low dose estrogen(0.3㎎) in postmenopausal osteopenia.
Materials and Method : We studied 70 women with postmenopausal osteopenia who visited at Department of rehabilitation medicine, Kosin Medical Center from march 2002 to may 2003. Subjects were divided in two groups : Gorup Ⅰ(n=30), treated with Fluocalcic^(?) (monofluorophosphate 100㎎+Calcium 500㎎), calcium(500㎎) and low dose estrogen, and Group Ⅱ(n=40), treated with estrogen(0.625㎎) and calcium (1.0g). BMD at the L-spine and femur, osteocalcin, deoxypyridinoline, and lipid profiles were measured at baseline and 1 year after treatment.
Result : 1) Average postmenopausal periods are 2.90yrs and 3.53yrs each other. 2) BMD increased significantly in two groups, and BMD in group I increased significantly more than that in groupⅡ. 3) Deoxypyridinoline decreased significantly in group Ⅰ, but decreased significantly in group Ⅱ. 4) Total cholesterol and LDL cholestero; decreased significantly in two groups, and no significant difference between two groups.
Conclusion : We concluded that combination therapy with fluocalcic^(?), calcium and low dose estrogen in postmenopausal osteopenia was more effective than combination therapy with estrogen and calcium to prevent postmenopausal osteoporosis.
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KEYWORD
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Postmenopausal osteopenia, Fluoride, Low dose estrogen, BMD
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